HIV/AIDS is a spectrum of diseases ranging from an initial infection
with the Human Immunodeficiency Virus (HIV) that eventually degenerates into full-blown Acquired Immunodeficiency Syndrome (AIDS). As drug research into HIV and AIDS proceeds, there is a persistent battle to lower against HIV drug costs and create generics. This battle has been set up subsequent to the principal drugs went ahead the business sector that successfully battles HIV and anticipates improvement of out and out AIDS. The truth of the matter is that the quickest developing territories of HIV disease is in creating nations without the assets to bring high-cost drugs to most tainted patients. That truth alone is the reason individuals around the globe are battling to inspire drugs to tainted patients quicker and much less expensive than the drug organizations might want.
Drug organizations are not in the business sector to individuals with compelling drugs without something consequently. They are in the business sector to make a benefit. And the more benefit they can make, the better off they are. Profoundly Active Antiretroviral Therapy (HAART) is a decent case of this. This is a blend of drugs that defers the onset of out and out AIDS. When it first came into the business sector, it could cost up to 15,000 USD per quiet for each year. That put the value well out of the span of a great many people contaminated by HIV. The drug organizations were making a phenomenal benefit, however millions kept on getting AIDS and kick the bucket. To turn this around, the business sector needed to cut down hostile to HIV drug costs and generics needed to go ahead the business sector.
A non specific producer in India brought a much less expensive adaptation of HAART onto the business sector. That opposition constrained the brand-name makers to bring down their costs. To cut things considerably facilitate down, governments, private associations, and activists from around the world put weight on the drug organizations. This had a significant impact. The vast drug organizations consented to bring down their costs. Yet, that did not end their journey to augment benefits. They sued South Africa’s legislature when it chose to place couple of confinements on non specific assembling or importation. In any case, weight from nations around the globe conveyed that to a stop. The battle proceeds for lower against HIV drug costs and generics. It is essential that consideration never falters to lower hostile to HIV drug costs and generics. Endeavors keep on attempting to adjust the requirement for drug organizations to benefit and the need of people to get by with HIV. Worldwide business and exchange assentions both make this less demanding and entangled. In any case, if consideration falters, the parity will tumble to the other side again and the battle will start from the very beginning once more.
AIDS is one of the first infectious diseases that we have not found an actual permanent treatment; Pharmaceutical companies all over the globe are racing to find a compound, vaccine or even a deterrent to prevent the spread of the disease through direct contact.
Fusion toxins are the world of the future: At present, there are several clinical trials on in Boston and Baltimore on the efficacy of the compound. Seragen INC, a pharmaceutical company, developed the product for use with several other diseases like lymphomas and rheumatoid arthritis. Promising results in the treatment protocol caused the company to ramp up research and testing on the HIV too. Fusion toxins are molecules created to bind to certain cells and prevent them from spreading.
They are also capable of releasing toxins that will kill or severely damage the bound cell. The HIV hides inside human CD4 cells, and these same cells are the primary targets for attack by the fusion toxin molecules. There is a potential risk that the fusion toxins can also kill completely healthy cells but clinical trials are on, and the results could be promising. If the treatment works then, the same fusion molecules could be used to send targeted medications directly to the infected cells in HIV as well as several other severe medical conditions.
Turning off the HIV: Long terminal repeat tails are the run off switches of the HIV. When the R switch or the Runoff Switch of the HIV is turned off, the virus cannot replicate to infect the human body. Researchers are taking an active interest in how the process works and whether the process can be carried out independently by an external chemical. At present researchers at the Dana Farber Cancer Research Institute have shortlisted three ingredients that can influence the LTR tails or the R switch of the HIV. They are curcumin, toptecan, and beta-lapachone that all show varying amounts of success. At present, more human testing is required before any conclusive results can be attained.
Preventing the formation of attachment proteins: When a person gets infected, the HIV attaches itself to a particular surface protein present on the surface of the CD4 lymphocyte. Researchers at the Naval Medical Research Institute are working to prevent CD4 cells from making the receptor cell. The main idea is to induce human cells to turn off the receptors that HIV prefers. Even though a significant amount of success has been achieved, it remains to be tested particularly in human patients.
All this may seem like too little too late but be rest assured that research companies are doing their best to find a permanent cure for the disease. All that we can do is hope and keep a positive attitude.
Over the past two decades, the government-funded researchers
to test aids drugs on hundreds of foster children. Most of these foster children were poor and the practice slowed their rate of death and extended their lives. Additionally, the children received care from excellent researchers at government expense. After several years, things changed because there were many reported children suffering from side effects of these drugs. Now, how are aids drugs tested today? Keep reading this article if you want to know more.
According to several studies, children suffered some side effects such as vomiting, rashes, and sharp drops in infection-fighting blood cells. Moreover, there were reported cases of overdose of the drug, and this
led to higher death rate among the children. In order to save the life of the children, the researchers decided to test the aids drugs on people who are infected with the disease.
These drugs destroy only the cells that are infected with the Aids virus, thereby leaving alone the other cells. Notably, the drug has been found to work on two different types of cells that act as a reservoir for the virus. These two cells include T-cells and macrophages and are very crucial to the healthy functioning of your immune system. Aids drugs prevent the virus from replicating in your T-cells.
From the above information, you can now see how aids drugs are tested. If you compare the previous method of test and the present, it is clear that the present method is the best since it does not put people on high risks. To many people, they may have been wondering how are aids drugs tested, but there you have all the answers you have been looking for. Besides, the (FDA) Food and Drug Administration has allowed the drugs to be tested on people infected with the disease.